Lurong Zhang, MD, PhD

Lurong Zhang, MD, PhDAdjunct Professor

Educational Background

  • MD, Medicine, Fujian Medical College, Fuzhou, China
  • PhD, Biochemistry/Immunology, Second Medical College, Shanghai, China
  • Postdoctoral Fellowship, Immunology/Pharmacology, Bristol-Myers Squibb Pharmaceutical Research Institute and Idaho State University
  • Postdoctoral Fellowship, Molecular Biology/Cancer Therapeutics, Georgetown University

Professional Societies and Committees

  • 1999-2003: Reviewer for basic, clinical, and translational research grants, Susan G. Komen Breast Cancer Foundation
  • 1996-present: Member, American Association for Cancer Research and Radiation Research Society

Honors and Awards

  • Casarett Research Award, University of Rochester

Research Areas

Dr. Zhang has explored several research areas since 1984, resulting in over 90 publications and 12 grants. Her work has focused on:

  • Biomarkers for liver fibrosis
  • The alteration of lymphocyte subsets in hepatitis and hematoma
  • An in vitro combined sensitivity assay for guiding the use of anti-tumor drugs in the treatment of acute leukemia
  • Luciferase activity as a marker of tumor burden and an indicator of tumor response to antineoplastic therapy
  • A solid-phase radioimmunoassay for cyclic AMP
  • Correlations between fibroblast growth factors and hormones in the proliferation, angiogenesis, and metastasis of breast cancer
  • The role of extracellular matrices (such as hyaluronan, extracellular matrix protein 1) in the progression of cancer
  • The role hyaluronan-binding proteins/peptides and hyaluronidase in cancer progression and regression
  • The role of RGD-tachyplesin in the inhibition of tumor growth and its action mechanism
  • The expression of DcR3, a decoy receptor in the TNFR family, in cancer and infectious diseases
  • The mitigatory effect of triptolide on tumors and radiation-induced inflammation
  • The effect of anti-apoptotic molecules in preventing radiation-induced damage

Current laboratory projects focus on:

  • Designing, synthesizing, and characterizing a small bioactive peptide for the mitigation of radiation-induced acute damage of bone marrow and the gastrointestinal system
  • Exploring agents that can increase the therapeutic gain of radiation treatment by sensitizing tumor cells to radiation and reducing radiation toxicity
  • Studying radiation-induced immunity in the eradication of tumor cells
  • Identifying the mechanism whereby small molecules, such as triptolide and cucurbitacin, are able to mitigate cancer and radiation-induced inflammation
  • Developing new forms of biodosimetry that determine radiation exposure for triage and help guide treatment following a nuclear event

A selection of publications available through PubMed.

Nationally ranked

U.S. News and World Report

Nationally ranked in 6 adult specialties and 6 pediatric specialties and rated high performing in 4 adult specialties and 5 procedures and conditions.

Award

defining optimal treatments

Annual Research Seminar

The seminar has three concurrent programs for radiation therapy, oncology nursing, and radiation oncology.

Seminar

EXPLORE THE

UF Health Cancer Center

Our Mission is to prevent, detect, treat and ultimately cure cancer while addressing the unique challenges of the cancer burden faced by the population we serve.

UF Health Cancer Center