SRS and FSRS are special techniques that rely on precise localization of target volumes based on 3D imaging. This allows clinicians to deliver higher than normal radiation dose in fewer fractions. At the University of Florida, single-fraction SRS for intracranial lesions is a joint effort between the departments of Radiation Oncology and Neurosurgery. UF is a renowned pioneer in linac-based SRS with more than 30 years of experience. A variety of benign, malignant, vascular, and functional lesions are treated with this technique. FSRS is administered using our state-of-the-art Versa HD LINAC with real-time surface imaging-guidance. Although called “radiosurgery”, SRS and FSRS are non-surgical outpatient treatment that are often an excellent alternative to surgery.