The Okunieff Lab is dedicated to the study of the normal tissue effects of radiation and the prevention and mitigation of radiotoxicity, with a particular emphasis on growth factors and their analogs. Currently funded projects include:
FGF-P: A Multipotential Mitigation Agent for Gastrointestinal Syndrome: This NIAID-funded project will determine if a fibroblast growth factor peptide (FGF-P) reduces acute radiation-induced gastrointestinal (GI) syndrome through a variety of cooperating mechanisms, including decreased cell loss and improved proliferation of small bowel mucosa, improved gut barrier function with reduced bacterial translocation, and support of bone marrow with induction of granulocyte-colony stimulating factor (G-CSF).
RadTox: Measuring Radiation Toxicity using Circulating DNA: The goal of this NIH SBIR-funded project is to provide a biomarker-based test that can predict the risk of developing severe radiotherapy-related complications. This subproject includes a clinical trial that has completed accrual.
Measurement of Individual Carcinogenesis Risk after Solar or Cosmic Radiation Exposure: This Florida Space Institute-funded project involves creating an individualized carcinogenesis detection kit by combining a modified QClamp kit with modified radiation biodosimetry reagents.