Research Publications

The University of Florida Department of Radiation Oncology has led research efforts in the field for 60 years. In fact, our residents are some of the most published residents of any radiation oncology residency program in the United States. Peruse our most recent publications and research highlights below:

Current Research Highlights

• Long-term outcomes following proton therapy for non-metastatic central nervous system germinoma in children and adolescents (Brisson et al), which presents the largest single institution experience utilizing proton therapy for the management of central nervous system pure germinoma in children and adolescents (growths of cells that form from reproductive cells).
• International Recommendations on Postoperative Management for Potentially Resectable Locally Recurrent Nasopharyngeal Carcinoma (Mendenhall et al), which provides international recommendations on postoperative management for potentially resectable locally recurrent nasopharyngeal carcinoma, with a special focus on postoperative re-irradiation.
• Investigating surface proteins and antibody combinations for detecting circulating tumor cells of various sarcomas (Siemann et al), which emphasizes the importance of studying cell surface proteins and subtype stratification for cancers as heterogeneous as sarcomas.
• Assessing safety and efficacy of a novel glucose-free amino acid oral rehydration solution for watery diarrhea management in children: a randomized, controlled, phase III trial (Vidyasagar et al), which indicates a promising avenue for improving pediatric diarrhea management worldwide.
• Survival (Time-To-Event) Curve Names and Endpoints (Cassidy et al), a resident-led research project that explains widely used names and event endpoints for survival analyses in a way that will help radiation oncologists consistently present and interpret experimental findings that influence clinical practice decisions.
• A summer course in cancer for high school students-an update on lessons taught and lessons learned (Siemann et al), which discusses the results of a cancer-focused, cooperative UF Health Cancer Center/UFSSTP summer learning program for high school students.
• A review on 4D cone-beam CT (4D-CBCT) in radiation therapy: Technical advances and clinical applications (Zhang et al), which comprehensively reviews the technical developments surrounding 4D-CBCT in order to provide a better understanding its capabilities and potential to enhance radiation therapy.

All Current Faculty Publications:

(please note that some may be in process)

September 2024

• Vincent D Cassidy, Ryan J Brisson, Robert J Amdur            

Survival (Time-To-Event) Curve Names and Endpoints. Cassidy VD, Brisson RJ, Amdur RJ. Pract Radiat Oncol. 2024 Aug 24:S1879-8500(24)00206-6. doi: 10.1016/j.prro.2024.08.002. Online ahead of print. PMID: 39187011.

• Daniel Indelicato                   

Evolution of Proton Radiotherapy Brainstem Constraints on the Pediatric Proton/Photon Consortium Registry. Correia D, Indelicato DJ, Paulino AC, Ermoian R, Mihalcik S, Perkins SM, Hill-Kayser C, Mangona VS, Lee J, Chang JH, Laack NN, Kwok Y, Perentesis J, Vatner R, Dave R, Gallotto SL, Lawell MP, Bajaj BVM, Allison KW, Perry A, Yock TI. Pract Radiat Oncol. 2024 Aug 9:S1879-8500(24)00194-2. doi: 10.1016/j.prro.2024.05.013. Online ahead of print.cPMID: 39128543.

• Jiyeon Park, Keaton Reiners, Soon Huh, Perry Johnson, Yawei Zhang                   

Investigation of linear energy transfer (LET)-dependence behavior and dosimetric response of a flat-panel detector in pencil beam scanning proton therapy. Jiyeon Park, Keaton Reiners, Meng Wei Ho, Soon Huh, Chunbo Liu, Perry Johnson, Yawei Zhang. Physica Medica, Volume 125, 2024, 104508. ISSN 1120-1797, https://doi.org/10.1016/j.ejmp.2024.104508. (https://www.sciencedirect.com/science/article/pii/S1120179724002539).

• Anusree Sasidharan, Astrid Grosche, Xiaodong Xu, Sadasivan Vidyasagar           

Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells. Sasidharan A, Grosche A, Xu X, Kinane TB, Angoli D, Vidyasagar S. PLoS One. 2024 Jul 25;19(7):e0307809. doi: 10.1371/journal.pone.0307809. eCollection 2024. PMID: 39052685.

• Dietmar Siemann                              

A summer course in cancer for high school students-an update on lessons taught and lessons learned. Solone, X.K., Chitre, S., Font, L.F. et al. BMC Med Educ 24, 1020 (2024). https://doi.org/10.1186/s12909-024-06002-z

• Yawei Zhang                          

A review on 4D cone-beam CT (4D-CBCT) in radiation therapy: Technical advances and clinical applications. Zhang Y, Jiang Z, Zhang Y, Ren L. Med Phys. 2024 Jun 23. doi: 10.1002/mp.17269. Epub ahead of print. PMID: 38922912. Please note: A figure from this review on 4D-CBCT was selected for the cover of the August edition of Medical Physics (below):

July 2024

• Vincent D Cassidy, Ryan J Brisson, Robert J Amdur            

The Radiation Oncology Match in 2024: Reason for Optimism. Bates JE, Amdur RJ, Lee WR.Pract Radiat Oncol. 2024 Jul-Aug;14(4):313-315. doi: 10.1016/j.prro.2024.04.007.PMID: 38942569.

• Ryan J Brisson, Daniel J Indelicato, Julie A Bradley, Vincent Cassidy, Christopher G Morris, Raymond B Mailhot Vega

Long-term outcomes following proton therapy for non-metastatic central nervous system germinoma in children and adolescents. Brisson RJ, Indelicato DJ, Bradley JA, Aldana PR, Klawinski D, Cassidy V, Morris CG, Mailhot Vega RB. Radiother Oncol. 2024 Jun 8:110371. doi: 10.1016/j.radonc.2024.110371. Online ahead of print. PMID: 38857699

• Nicolette R Drescher, Tayna Latortue, Ryan J Brisson, Vincent D Cassidy, Robert J Amdur, William M Mendenhall, Kathryn E Hitchcock

Flap Reconstruction Results in Longer Overall Treatment Time in Patients Treated With Surgery and Adjuvant Radiotherapy for Carcinoma of the Oral Cavity and Larynx. Drescher NR, Latortue T, Brisson RJ, Cassidy VD, Amdur RJ, Mendenhall WM, Hitchcock KE.Am J Clin Oncol. 2024 Jul 1;47(7):305-310. doi: 10.1097/COC.0000000000001090. Epub 2024 Feb 29.PMID: 38421015

• William Mendenhall

International Recommendations on Postoperative Management for Potentially Resectable Locally Recurrent Nasopharyngeal Carcinoma. Li JS, Blanchard P, Wong CHL, Ahn YC, Bonomo P, Bresson D, Caudell J, Chen MY, Chow VLY, Chua MLK, Corry J, Dupin C, Giralt J, Hu C, Kwong DLW, Le QT, Lee AWM, Lee NY, Li Y, Lim CM, Lin JC, Mendenhall WM, Moya-Plana A, O’Sullivan B, Ozyar E, Pan J, Qiu Q, Sher DJ, Snyderman CH, Tao Y, Tsang RK, Wang X, Wu P, Yom SS, Ng WT. Int J Radiat Oncol Biol Phys. 2024 Jul 13:S0360-3016(24)02954-7. doi: 10.1016/j.ijrobp.2024.07.2143. Epub ahead of print. PMID: 39009321.

• Dietmar W Siemann

1. 1. A Novel Ex Vivo Tumor Spheroid-Tissue Model for Investigating Microvascular Remodeling and Lymphatic Blood Vessel Plasticity. Lampejo AO, Lightsey SE, Gomes MC, Nguyen CM, Siemann DW, Sharma B, Murfee WL. Ann Biomed Eng. 2024 May 25. doi: 10.1007/s10439-024-03535-8. Online ahead of print. PMID: 38796670.
   2. Investigating surface proteins and antibody combinations for detecting circulating tumor cells of various sarcomas. Le MN, Smith KA, Dopico PJ, Greer B, Alipanah M, Zhang Y, Siemann DW, Lagmay JP, Fan ZH. Sci Rep. 2024 May 29;14(1):12374. doi: 10.1038/s41598-024-61651-w. PMID: 38811642.

• Wen-Chih Tseng

An automation of Monte Carlo workflow for dosimetry study of an Elekta LINAC delivery system in radiotherapy. Tseng W, Furutani K, Beltran C, Lu B. Tech Innov Patient Support Radiat Oncol. 2024 Jun 13;31:100257. doi: 10.1016/j.tipsro.2024.100257. eCollection 2024 Sep. PMID: 39027884.

• Sadasivan Vidyasagar

Assessing safety and efficacy of a novel glucose-free amino acid oral rehydration solution for watery diarrhea management in children: a randomized, controlled, phase III trial. Bardhan, Pradip Kumar et al. eClinicalMedicine (part of The Lancet Discovery Science), Volume 72, DOI:https://doi.org/10.1016/j.eclinm.2024.102630